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Regular monitoring and shared decision-making between patient and clinician remain essential throughout the treatment course

Hormonal Changes: Fluctuations in hormones lead to increased melanin production in the face, which occurs mainly in three conditions: pregnancy, menstruation, and hormone replacement therapy

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Ultrathin sections, unstained or post- stained with uranyl acetate and lead hydroxide were examined under a Morgagni 268D TE microscope (FEI, Hillsboro, OR) equipped with a Mega View II charge-coupled device camera (SIS, Soft Imaging System GmbH, Munster, Germany) and analyzed with AnalySIS software (SIS)