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Importantly, because these peptides are often lacking large high-quality clinical trials, we do have to make our decisions based upon lower level evidence, which is OK in my opinion, as long as everybody feels adequately informed about the potential risks and benefits

Available from: Accessed: 19 Sep 2025 Jastreboff AM, Kaplan LM, Fras JP et al (2023) Triplehormone-receptor agonist retatrutide for obesity: a phase 2 trial

The lower chamber was added with various materials supplemented with 10% FBS, while serum-free DMEM was added to the upper chamber