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Although necroptosis, a regulated form of necrosis, has been speculated to possibly mediate APAP-induced liver injury, its contribution to APAP hepatotoxicity is still unclear (Dara et al., 2015, 2016)

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3.4 Tirzepatide restores -cell function through upregulation of FOXO1 Given that FOXO1 serves as a central regulator of the FOXO pathway and plays a critical role in maintaining -cell identity, oxidative defense, and insulin gene expression [6], we then examined the levels of FOXO1 and its phosphorylation state (p-FOXO1) in -cell