Strain Route of Administration Dose Period of Administration Parameter Investigated Reference SAMP-1 Subcutaneous injection 1g/mouse, 5 times a week 10 months Incidence of chromosome aberrations [62] SAMR-1 Subcutaneous injection 1g/mouse, 5 times a week 10 months Incidence of chromosome aberrations [62] SHR Subcutaneous injection 1g/mouse, 5 times a week 10 months Incidence of chromosome aberrations [62] 9 months Incidence of chromosome aberrations in bone marrow [63] Until natural death Body temperature, life span, food consumption, estrous function, and weight [63] CBA Subcutaneous injection 0.1 g/mouse, 5 times a week Until natural death Body weight and food consumption dynamics, physical activity, age-related estrus functionality, body temperature, muscular strength and physical fatigability, longevity, and carcinogenesis [65] 1 day Free radical processes [65] 1g/mouse, everyday 5 days Gene expression in heart [74] Int
Both oral administration in drinking water and intraperitoneal injection produced significant pressure increases, though direct gastric application showed effects within minutes
Some small studies show mild skin-lightening effects with high-dose oral glutathione
Pyridoxine HCL is the more common type and is usually found in cheaper supplements
