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GLP-1 (Glucagon-like peptide-1): GLP-1 is a peptide hormone secreted by intestinal L cells after food intake, exhibiting multiple physiological effects
(Oxf.) 68 , 213219 (2008)
Importantly, not all variants confer increased risk: loss of function variants in HSD17B13, a lipid droplet-associated protein in hepatocytes, have been consistently associated with reduced hepatic inflammation and a lower risk of fibrosis and advanced liver disease [16]
Furthermore, semaglutide treatment resulted in a significantly higher percentage of patients with NASH resolution than placebo in the phase II trial involving patients with NASH [80]
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