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Seizure 44:147156 Kovac S, Dinkova Kostova AT, Herrmann AM et al (2017) Metabolic and Homeostatic changes in seizures and acquired epilepsy-mitochondria, calcium dynamics and reactive oxygen species [J]

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DZN's inhibition of acetylcholinesterase (AChE) increases sympathetic nervous system activity and indirectly causes hepatic stress, and induction of oxidative stress (OS) leads to the generation of free radicals such as reactive oxygen species (ROS) contributes to damage cellular lipids, proteins, and DNA, leading to lipid peroxidation, nitric oxide reaction, and mitochondrial damage, which in turn affects the membrane permeability and allows the enzymes to leak into circulation