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In ADPKD patients, the expression levels of GPX4, SLC3A2, and SLC7A11 are significantly downregulated in the kidneys compared to normal kidneys, while the expression of TFR1 and divalent metal transporter 1 is markedly upregulated

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All randomized participants were planned to undergo a 72week treatment period (primary study period) that included a doseescalation period of up to 20 weeks and allowed for 52 weeks of followup on the highest dose (15 mg)