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[76] have developed a lipase-labile prodrug of fumagillin (Fum-PD) with Sn2 translatable moiety, which overcomes the photo-instability and enhances drug retention in circulation for improved delivery to angiogenic endothelial cells via CFDD

Furthermore, the present in vitro and in vivo data were corroborated by clinical sample analyses, which revealed that high GLP-1R expression in patients with CRC undergoing ICI therapy was closely associated with a poor treatment response, underscoring the potential of GLP-1R as a negative predictive biomarker in immunotherapy