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User-reported regimens vary, with some individuals starting at very low doses like 0.25 mg in week 1 to assess tolerance and reduce potential side effects, while a frequently described unofficial regimen involves once-weekly subcutaneous injections with the following schedule: Weeks 14 at 1 mg, Weeks 58 at 2 mg, Weeks 912 at 4 mg, Weeks 1316 at 8 mg, and thereafter up to 12 mg weekly if tolerated

They found a small but statistically significant antidepressant effect (SMD = 0.12), offering the strongest evidence for potential mood benefits

As depicted in the graph below, Virginia Medicaids gross spending on GLP-1s for weight loss increased from $3.9 million to $15.63 million per quarter since 2023

Some people find that a microdosing approach provides the benefits they want without the side effect burden of higher doses