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Disruption of estrogen signaling in zebrafish retina using known estrogen receptor modulators such as tamoxifen and 4-OH-A (formestane) alter eye development and retinal thickness 94 , suggesting proper estrogenic signaling is important for normal eye development

"Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis." Proc Natl Acad Sci