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Cloning and characterization of the human selenoprotein p promoter: response of selenoprotein P expression to cytokines in liver cells

Additionally, ROS-induced oxidative modifications of cellular macromolecules generate damage-associated molecular patterns (DAMPs), which are recognized by pattern recognition receptors, such as Toll-like receptors (TLRs), thereby perpetuating sterile inflammatory responses (Koenig and Buskiewicz-Koenig, 2022)

In 2014, Saxenda became the first GLP-1 analog approved for weight loss, and in 2021, semaglutide (Wegovy), became the second GLP-1 analog to receive this indication