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The cardiovascular benefit appears to be partially independent of the weight loss itself, suggesting direct vascular and anti-inflammatory mechanisms beyond caloric reduction

Rich and minimal yeast medium was as described in [41], and gliotoxin was added to the desired concentration to cooled molten agar

2017;5(23):e13503

[PMC free article: PMC3622763] [PubMed: 23352659] (The antimitochondrial antibody of primary biliary cirrhosis binds to the lipoic acid moiety of the E2 domain of pyruvate dehydrogenase and effectively blocks the activity of the enzyme)