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True Bugs ( Hemiptera ) Insects such as stink bugs and aphids undergo this type of metamorphosis, transitioning from nymphs to adults without a pupal stage

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doi: 10.1093/esr/jcp018 19 HennM.SloamJ.NunesA

That would be far more effective than anything we could possibly achieve by finding a more effective drug, realistically. Although not a new drug it has been used in some eastern European countries for decades the first modern trial of cytisine is a bright spot on the horizon