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Semaglutide may affect sebaceous gland function and cutaneous immune responses due to its strong metabolic effects, which include reduced lipogenesis, appetite suppression, and modulation of adipose-derived inflammatory pathways [9,10]

Anyone who develops severe, persistent abdominal pain should stop treatment and seek urgent medical advice

Mutations in genes like AKR1C1 (linked to adipogenesis and progesterone levels) and PIT1 (involved in growth and sex hormones) have been found in affected families.13,14AKR1C1 mutation is believed to reduce aldo-keto reductase activity, increasing levels of allopregnanolone (a potent analgesic) while also decreasing prostaglandin F2-alpha levels and raising progesterone levels, which stimulate adipogenesis.15 The disproportionate accumulation of adipose tissue in the lower body, particularly coinciding with periods of hormonal fluctuation, suggests that dysregulation of estrogen signaling plays a key role in the pathophysiology of lipedema

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