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In summary, the literature reviewed suggests that iron competition within the TME is dynamic and influenced by oxygen levels, cytokines and immune cell states (Fig

Its efficacy is thought to be due to a reduction in collagen formation via decreasing serotonin levels, increasing monoamine oxidase activity, and inhibiting fibroblast glycosaminoglycan secretion (6)

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All mice were able to intermittently obtain one bottle of ethanol and one bottle of water with progressively increased concentrations of ethanol and water as described above (24-h period, 4 days/week)