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Direct injection onto the lyophilised powder at high velocity creates localised turbulence that disrupts hydrogen bonds holding the protein in its biologically active conformation

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Decreased expression of GPx1 by iberin results in an accumulation of detrimental concentrations of ROS (measured by DCF fluorescence) that inhibits cell proliferation, induces cell cycle arrest, and promotes apoptosis, whereas the forced upregulation of GPx1 or antioxidant treatment attenuates these therapeutic actions [143]

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