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Name: what is best glp 1 for weight loss GLP-1 the Same as Ozempic? Best GLP-1 Medications for Weight
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Experienced clinicians recognize this pattern

Dual agonists (GIP/GLP-1 medications) work on two incretin pathways at once

Hirano K, Ogihara T, Miki M, Yasuda H, Tamai H, Kawamura N, and Mino M (1994)

195,196,197 At the cellular level, this translates into a massive increase in cytoplasmic Na + concentration, membrane depolarisation and opening of voltage-gated Ca 2+ channels, which in turn promotes massive release of glutamate that results in even large depolarisation enlarging Na + and Ca 2+ influx thus completing the vicious circle of excitotoxic damage, as Ca 2+ overload triggers necrotic cell death